PHASE II TRIAL OF AKT INHIBITOR MK-2206 IN PATIENTS WITH ADVANCED BREAST CANCER WHO HAVE TUMORS WITH PIK3CA OR AKT MUTATIONS, AND/OR PTEN LOSS/PTEN MUTATION

Abstract Background The PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations and PTEN loss in breast cancer.We conducted a phase II trial with an allosteric AKT inhibitor MK-2206 in patients with advanced breast cancer who had tumors with PIK3CA/AKT1 mutations and/or PTEN loss/mutation.Methods The primary endpoint was objective response r

Deep submicron technologies continue to develop according to Moore’s law allowing hundreds of processing elements and memory modules to be integrated on a single chip forming multi/many-processor systems-on-chip (MPSoCs).Network on chip (NoC) arose as an interconnection for this large number of processing modules.However, the aggressive scali

The translation is a process that goes beyond linguistic transformations and demands cross-cultural awareness.However, mistakes resulting from apparently similar linguistic structures in the source and target language as well as narrow cultural views can compromise the quality of the translated text.Therefore, the target audience may lose the threa

Sweet sorghum (Sorghum saccharatum) Face Serum silage, maize (Zea mays) silage, and sorghum and maize (1:1) silage were investigated.The silages were analysed for chemical composition, quality and aerobic stability.Dry matter was the lowest (20.88%) in sorghum silage and the highest (37.45%) in maize silage.In sorghum silage, the concentration of c

Flooding fault diagnosis is critical to the stable and efficient operation of fuel cells, while the on-board embedded controller has limited computing power and sensors, making it difficult to incorporate the complex gas-liquid two-phase flow models.Then in fuel cell system for cars, the neural network modeling is usually regarded as an appropriate